Select the procedures you wish to compare by clicking on the navigation pills above the table. This allows you to customize the view, focusing on the treatments relevant to you. The table provides essential details such as expected weight loss, major risks, benefits, indications for use, and more, to help you make informed decisions.
| Gastric Bypass | Gastric Sleeve | Gastric Band | Endoscopic Sleeve Gastroplasty | Gastric Balloon | Plenity | Orlistat | Phentermine | Qsymia (Phentermine/Topiramate) | Contrave (Bupropion/Naltrexone) | Saxenda (Liraglutide) | Wegovy (Semaglutide) | Tirzepatide (Mounjaro) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Expected Weight Loss | 70-80% of excess weight in 12-18 months | 60-70% of excess weight in 12-18 months | 40-50% of excess weight in 2 years | 15-20% of total body weight in 12 months | 10-15% of total body weight in 6 months | 5-10% of total body weight in 6 months | 5-10% of total body weight in 6 months | 5-10% of total body weight in 3-6 months | 10-15% of total body weight in 12 months | 5-10% of total body weight in 12 months | 10-15% of total body weight in 12 months | 15-20% of total body weight in 12 months | 20-25% of total body weight in 12 months |
| Major Risks | Dumping syndrome, nutritional deficiencies, bowel obstruction | Nutritional deficiencies, acid reflux, staple line leaks | Band slippage, erosion, port infection | Stomach perforation, bleeding, infection | Balloon deflation, gastrointestinal blockage, nausea | Gastrointestinal discomfort, potential blockage if not taken with water | Gastrointestinal issues, liver injury, kidney stones | High blood pressure, heart palpitations, insomnia, dependency | Birth defects if taken during pregnancy, cognitive side effects | Nausea, constipation, dizziness, increased blood pressure | Nausea, vomiting, pancreatitis, thyroid tumors | Nausea, vomiting, pancreatitis, gallbladder issues | Nausea, diarrhea, pancreatitis, gallbladder issues |
| Major Benefits | Significant and rapid weight loss, improvement in obesity-related conditions | Significant weight loss, no foreign objects left in the body | Adjustable and reversible, lower complication rate | Minimally invasive, significant weight loss | Temporary, non-surgical option for weight loss | Non-systemic, FDA-approved for overweight and obesity management | Reduces fat absorption, can be used long-term | Short-term weight loss, appetite suppression | Appetite suppression, enhanced weight loss compared to phentermine alone | Appetite suppression, improvement in mood | Significant weight loss, improvements in blood sugar control | Significant weight loss, improvements in blood sugar control | Significant weight loss, improvements in blood sugar control |
| Indications for Use | BMI ≥ 40, or BMI ≥ 35 with comorbidities | BMI ≥ 40, or BMI ≥ 35 with comorbidities | BMI ≥ 40, or BMI ≥ 35 with comorbidities | BMI ≥ 30 | BMI 30-40 | BMI 25-40 | Obesity, overweight with comorbidities | Short-term weight management | Obesity, overweight with comorbidities | Obesity, overweight with comorbidities | Obesity, overweight with comorbidities | Obesity, overweight with comorbidities | Obesity, type 2 diabetes |
| Mechanism of Action | Restricts food intake and reduces nutrient absorption | Restricts food intake by reducing stomach size | Restricts food intake by placing a band around the stomach | Endoscopic suturing reduces stomach volume | Occupies space in the stomach to promote satiety | Absorbs water and expands in the stomach | Inhibits pancreatic lipase, reduces fat absorption | Sympathomimetic amine, reduces appetite | Appetite suppression, satiety enhancement | Affects appetite and reward centers in the brain | GLP-1 receptor agonist, reduces appetite | GLP-1 receptor agonist, reduces appetite | Dual GIP and GLP-1 receptor agonist, reduces appetite |
| Age of Indication | 18 and older | 18 and older | 18 and older | 18 and older | 18 and older | 22 and older | 12 and older | 16 and older | 18 and older | 18 and older | 12 and older | 18 and older | 18 and older |
| Contraindications | Severe heart/lung disease, substance abuse | Severe heart/lung disease, substance abuse | Severe heart/lung disease, substance abuse | Severe heart/lung disease, gastrointestinal conditions | Hiatal hernia, prior GI surgery, pregnancy | Esophageal abnormalities, gastrointestinal conditions | Chronic malabsorption syndrome, cholestasis | Cardiovascular disease, hyperthyroidism, pregnancy | Pregnancy, glaucoma, hyperthyroidism, MAOI use | Uncontrolled hypertension, seizure disorders, pregnancy | Medullary thyroid carcinoma, multiple endocrine neoplasia | Medullary thyroid carcinoma, multiple endocrine neoplasia | Medullary thyroid carcinoma, multiple endocrine neoplasia |
| Black Box Warning | None | None | None | None | None | None | None | None | Teratogenic risk | Suicidality and neuropsychiatric reactions | Risk of thyroid C-cell tumors | Risk of thyroid C-cell tumors | Risk of thyroid C-cell tumors |
| Common Use Cases | Severe obesity, type 2 diabetes, hypertension | Severe obesity, type 2 diabetes, hypertension | Severe obesity, type 2 diabetes, hypertension | Obesity management | Short-term obesity management | Overweight, obesity management | Long-term obesity management | Short-term obesity management | Obesity, type 2 diabetes, hypertension | Obesity, weight management with mood disorders | Obesity, type 2 diabetes, weight management | Obesity, type 2 diabetes | Obesity, type 2 diabetes |
| Caution in Patients With | Malabsorption syndromes, osteoporosis, anemia | Gastroesophageal reflux disease (GERD) | Upper gastrointestinal issues, prior gastric surgery | Severe gastrointestinal disease, prior abdominal surgery | Severe gastrointestinal disease, previous GI surgery | Gastrointestinal disorders, difficulty swallowing | Liver disease, kidney stones | Cardiovascular conditions, history of drug abuse | Seizure disorders, kidney stones | Depression, cardiovascular disease | Pancreatitis, thyroid disease | Pancreatitis, severe gastrointestinal disease | Pancreatitis, gallbladder disease |
